Khirurgiia (Mosk). 2026;(5):50-59. doi: 10.17116/hirurgia202605150.
ABSTRACT
AIM: To evaluate postoperative changes in the amino acid profile in oncological surgery patients in the ICU, as well as the dynamics of integrated indices (BCAA/AAA, UreaCycle, Arg/Orn/Cit) against the background of combined nutritional support.
MATERIAL AND METHODS: A secondary analysis of data from a prospective, two-center, randomized study was conducted. Participants (aged 18-80 years, n=120) received parenteral protein-carbohydrate nutrition for ≥5 days and were randomized (1:1) into two groups: «Aminoven 10%» or «Aminoparcentin» (10 mL/kg+10% dextrose alongside early enteral feeding). Amino acid profiles (arginine, BCAA, AAA, ornithine, citrulline, etc.), as well as cystatin C, malondialdehyde, SOFA score, nitrogen balance, and albumin, were assessed at three time points (T0, T1, T2). Statistical analysis: non-parametric methods, Me [Q1; Q3], Mann-Whitney U test, Wilcoxon test, Spearman’s rank correlation.
RESULTS: At the T0 stage, an amino acid imbalance was identified (decreased BCAA/AAA ratio, urea cycle instability, elevated malondialdehyde levels). Against the background of nutritional support in both groups, the BCAA/AAA ratio improved, the integrated UreaCycle_sum index stabilized, and ornithine-citrulline ratios normalized. The dynamics of the indices were comparable between the groups (p>0.05) and correlated with SOFA score, malondialdehyde, and nitrogen balance (ρ=0.4-0.6; p<0.05), with a weak correlation observed for cystatin C.
CONCLUSION: Cancer patients following abdominal surgery exhibit a pronounced amino acid imbalance that is partially correctable by combined nutritional support. The BCAA/AAA, UreaCycle, and arginine indices reflect the metabolic response and correlate with disease severity and nitrogen balance. The rate of correction of these disorders is comparable in both the group receiving Aminoven 10% and the group receiving Aminoparcentin.
CONFLICT OF INTEREST: The authors declare no conflict of interest.
FINANCIAL SUPPORT: The study was supported by the manufacturing company «Medical Leasing-Consulting» LLC, which provided the investigational drugs (Aminoparcentin and Aminoven 10%) and financial support for the organization of laboratory tests, as well as for the publication of the article in the journal. The sponsor did not participate in the analysis of the results obtained, statistical processing, or writing of the manuscript.
PMID:42160147 | DOI:10.17116/hirurgia202605150
