Efficacy and Tolerability of a Cream in Aging Skin

J Drugs Dermatol. 2025 May 1;24(5):524-529. doi: 10.36849/JDD.9025.

ABSTRACT

BACKGROUND: The clinical presentation of photodamaged and aged skin includes fine lines, wrinkles, and pigmentation changes, which are related to the amount of water in the epidermis. Use of moisturizing products can help improve signs of aging.

METHODS: Twelve (12) week single-center study in participants 40 to 75 years old with sensitive skin and signs/symptoms of photodamage and skin aging (defined as mild-to-moderate wrinkles, overall photodamage, and lack of skin tone evenness on the neck and outer forearms). Participants applied a cream twice per day to the body (neck, legs, arms, and hands). Efficacy was assessed by clinical grading and digital imaging (in a subgroup of 19 participants) and standard safety assessments were performed.

RESULTS: A total of 41 participants participated. All clinical grading parameters showed significant improvements, including crepiness (visual), skin texture/smoothness (tactile), and overall quality/appearance. In addition, density/thickness improved on both neck and limbs throughout the study. Pinch recoil measurements also improved from baseline to day 84. Tolerability assessments showed improvement of dryness and scaling on limbs vs baseline and no measurable change in any other tolerability parameters throughout the study. In addition, participants reported a positive impression of the cream on a self-assessment questionnaire.

CONCLUSIONS: The tested cream, which incorporates the ingredients mandelic acid and Centella asiatica, effectively improved participants’ skin appearance in adults with sensitive skin and moderate signs of aging.

CITATION: Widgerow A, Grivet-Seyve M, Anjuwon S, et al. Efficacy and tolerability of a cream in aging skin. J Drugs Dermatol. 2025;24(5):524-529. doi:10.36849/JDD.9025.

PMID:40327578 | DOI:10.36849/JDD.9025