Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of low-intensity pulsed ultrasound on clinical parameters in atherosclerotic peripheral artery disease patients with chronic limb-threatening ischemia
Chronic limb-threatening ischemia (CLTI) is a major public health problem. Low-intensity pulsed ultrasound (LIPUS) has been shown to improve ischemic limb conditions in patients with CLTI. However, the possible mechanisms of these benefits require further understanding. A total of 37 atherosclerotic peripheral artery disease patients with CLTI (Fontaine class III or IV) who were not…
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The comparative study of letibotulinum toxin A and onabotulinum toxin A in treatment of primary axillary hyperhidrosis
Primary axillary hyperhidrosis (PAH) is a challenging condition characterized by excessive underarm sweating. The U.S. Food and Drug Administration has approved onabotulinum toxin A (OnaBTX-A, Botox^(®), Allergan Inc, USA) as the only botulinum toxin treatment for severe axillary hyperhidrosis, and it has demonstrated positive results. Recently, the off-label use of letibotulinum toxin A (LetiBTX-A, Hugel^(®),…
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Protocol for a Randomized Controlled Trial to Enhance Executive Function via Brief Mindfulness Training in Individuals with Internet Gaming Disorder
BACKGROUND: Internet Gaming Disorder (IGD) is characterized by uncontrolled gaming behavior, leading to emotional distress, neglect of academic or life responsibilities, and damage to interpersonal relationships, all of which have serious negative impacts on individuals and society. IGD has been associated with neuropsychological impairments, especially executive function deficits, and emotional difficulties. Mindfulness interventions have been…
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Fractional CO2 laser with topical insulin versus PRP for atrophic acne scars: a randomized split-face study
Atrophic acne scarring is a prevalent problem that has been treated with a variety of procedures, each with various degrees of success. For better results, combined regimens of treatment are recommended. Our aim was to compare the efficacy of topical insulin against topical platelet-rich plasma (PRP) as an adjunct treatment to fractional CO2 laser for…
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The efficacy of topical cetirizine using microneedling in androgenetic alopecia male patients
CONCLUSION: The microneedling of 1% topical cetirizine proved efficient in promoting hair growth without problems in the treatment of male androgenetic alopecia.
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Efficacy of intradermal tranexamic acid injection following IPL for the treatment of persistent post acne erythema: a split-face, controlled trial
Post-acne erythema (PAE) is a common consequence of acne vulgaris, often leading to significant psychological distress and social impairment. While Intense Pulsed Light (IPL) has been proven as a non-invasive option for reducing erythema, the addition of adjunctive therapies may enhance treatment outcomes. To evaluate the effects of intradermal tranexamic acid (TXA) injections on the…
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A qualitative exploration of factors that influence engagement with a digital mental health intervention for women with metastatic breast cancer: Finding My Way-Advanced
CONCLUSIONS: This study confirms that while many DMHI facilitators and barriers are consistent with those identified in curatively treated settings, some factors become more salient in metastatic populations (e.g., time burden). This research also offers novel insights that deriving early personal benefit promotes engagement and provides targets for future program improvements to address navigation and…
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Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes trial (TC4): a Bayesian pragmatic cluster randomized controlled trial
BACKGROUND: Dual antiplatelet therapy is the standard of care for acute coronary syndrome, but uncertainty exists regarding the optimal regimen for patients in North America. We sought to compare the effectiveness and safety of acetylsalicylic acid (ASA) and ticagrelor or clopidogrel in patients with acute coronary syndrome from a single tertiary academic centre in Montréal,…
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Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial
CONCLUSIONS: The videoconference-delivered ACT program showed promise in improving mental health outcomes and ACT processes among family caregivers with depression who give care to individuals with dementia. Future studies should aim to replicate these findings with larger, more diverse caregiver populations and explore the long-term efficacy of videoconference-delivered ACT programs.
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Effectiveness of Massage Gun Versus Myofascial Release Technique for Releasing Latent Trigger Points of the Calf Muscle: A Protocol for Randomized Clinical Trial
BACKGROUND AND PURPOSE: Trigger points can disrupt muscle activity patterns and cause cramping, fatigue, and weakening. Massage guns and myofascial release are widely employed for such circumstances, but their isolated outcomes are unknown. This study aimed to compare the effectiveness of a massage gun versus myofascial release technique on subjective pain, pain pressure threshold and…