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Evaluation of clinical efficacy of pelvic ultrasound monitoring combined with scale scoring in the treatment of interstitial cystitis by intravesical instillation regimen combined with hydrodistention and transurethral fulguration
CONCLUSIONS: Intravesical instillation of heparin/alkalized lidocaine combined with hydrodistention and transurethral fulguration is an effective treatment for interstitial cystitis, which can significantly reduce patient pain and improve patient prognosis. Moreover, the use of pelvic ultrasound to monitor indicators such as bladder volume at maximum filling state and residual urine volume, combined with ICSI, ICPI, PUF,… →
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Zirconia-reinforced glass ionomer restorations in molar incisor hypomineralization: a randomized controlled clinical trial
CONCLUSION: Regarding the reduction of pain and sensitivity, and clinical success, zirconia-reinforced GIC was as effective as glass hybrid GIC in restoring HPFM, using the ART approach. →
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Effects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial
CONCLUSIONS: In adults with symptoms of PTSD after critical illness, a brief narrative exposure intervention was feasible and showed a reduction of symptoms, which was less than the predefined minimal clinically important difference. The effect was found to be sustained at 12 months’ follow-up. These findings support the further evaluation of this intervention in primary… →
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Effectiveness and cost-effectiveness of Chuna manual therapy for temporomandibular disorder: A randomized clinical trial
The effectiveness and cost-effectiveness of Chuna manual therapy (CMT) for temporomandibular joint disorders (TMD) remain unclear. Here, we compared the effectiveness of CMT and usual care for treating myofascial TMD. A 26-week randomized controlled trial was conducted from 2018 to 2019 with 80 patients across five hospitals in Korea who were diagnosed with myofascial TMD… →
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Long-Term Safety and Efficacy of a Water-Free Cyclosporine 0.1% Ophthalmic Solution for Treatment of Dry Eye Disease: ESSENCE-2 OLE
CONCLUSIONS: The water-free cyclosporine 0.1% ophthalmic solution was safe and well tolerated during long-term use. The results demonstrated sustained 1-year efficacy, in both signs and symptoms of DED, and may help understand short and long-term healing dynamics in a predominant inflammatory DED population. →
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GTM 145: What Happens When a CRO Owns the Entire Customer Journey, How to Build a Unified GTM Engine | Marcy Campbell
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Marcy Campbell is the Chief Revenue Officer at AppFolio, where she leads sales and client services with a focus on delivering unified, end-to-end customer experiences. With over 30 years of experience scaling revenue teams across FinTech, SaaS, cloud computing, and communications,… →
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WorkFusion vs Capgemini: End-to-End Automation to Scale Your Product
WorkFusion automates end-to-end business processes like customer onboarding enhancing scalability Reducing reliance on outsourced teams by 50% cuts labor costs Equivalent products from the list include Cognizant AI Solutions or Capgemini AI Services →
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Enzalutamide and Prostate-Specific Antigen Levels in Metastatic Prostate Cancer: A Secondary Analysis of the ARCHES Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial, patients with mHSPC treated with enzalutamide plus ADT vs placebo plus ADT had improved clinical outcomes regardless of PSA level at enrollment. Undetectable PSA was associated with improved clinical outcomes with enzalutamide treatment. Future studies are required to further characterize the clinical utility… →
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Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder
Background: Posttraumatic stress disorder (PTSD) is a severe condition often complicated by co-occurring disorders, such as major depression, alcohol use disorder, and substance use disorders. A well-powered phase 3 randomized, placebo-controlled trial has shown that MDMA-assisted therapy (MDMA-AT) may be an effective treatment for severe PTSD. However, the psychological mechanisms driving the therapeutic effects of… →
