Wounds. 2025 Nov;37(11):417-425. doi: 10.25270/wnds/25012.
ABSTRACT
BACKGROUND: Photobiomodulation has shown promising results in accelerating wound healing and modulating inflammation.
OBJECTIVE: To evaluate the feasibility of photobiomodulation therapy in treating lower limb wounds in people with diabetes.
MATERIALS AND METHODS: This was a 12-week prospective, pilot, multicenter, nonrandomized clinical trial. The 25 participants were divided into the intervention group, in which a laser was applied once a week and hydrogel was applied daily, and the control group, in which hydrogel was applied daily. Participants older than 18 years with a diagnosis of diabetes mellitus and with lower limb wounds smaller than 100 cm² were included. Participants with lupus, pyoderma gangrenosum, and Stevens-Johnson syndrome were excluded. Comparisons between the groups were performed using the Mann-Whitney U test, and comparisons between different time points were performed using the Friedman test. The Fisher exact test was used to assess associations between groups and qualitative variables.
RESULTS: No statistically significant difference in wound area was observed when comparing the 4 time points evaluated between groups. However, there was a significant difference when comparing the 4 time points in the intervention group. No significant difference between groups was observed in the expression of the cytokines investigated.
CONCLUSION: Application of photobiomodulation at an intensity of 2 J/cm² once a week did not produce measurable changes in cytokine gene expression. However, significant reduction in wound area and improvement in tissue repair were observed in patients treated with photobiomodulation.
PMID:42013218 | DOI:10.25270/wnds/25012
