Drug Des Devel Ther. 2026 Mar 25;20:588535. doi: 10.2147/DDDT.S588535. eCollection 2026.
ABSTRACT
PURPOSE: Ivor Lewis esophagectomy impacts circulatory and cardiac function significantly, often leading to elevated postoperative troponin levels. This study aimed to investigate the effect of low-dose esketamine on postoperative levels of the myocardial injury marker high-sensitivity cardiac troponin T in elderly patients undergoing this procedure.
PATIENTS AND METHODS: 70 elderly patients scheduled for elective Ivor Lewis esophagectomy were randomly assigned using a random number table to the Control group (Group C, n=35) or the Esketamine group (Group K, n=35). In Group K, in addition to conventional anesthetic drugs, intravenous esketamine 0.25 mg/kg was administered during anesthesia induction, followed by continuous intraoperative infusion at 0.125 mg/kg/h as an adjunct to balanced anesthesia. The Control group received conventional anesthesia induction and maintenance. The primary outcome was hs-cTnT concentration at 24 h postoperatively.
RESULTS: In Group K, hs-cTnT concentrations were significantly lower than in the control group at 24h (12.1 ± 3.5 vs 18.7 ± 4.7, P < 0.0001) postoperatively, as well as at 6-12h and 48h postoperatively. Although the incidence of myocardial injury within 2 days postoperatively (11.4% vs 22.9%, P = 0.205) and perioperative severe arrhythmias (2.9% vs 11.4%, P = 0.164) was lower in Group K than in Group C, the differences were not statistically significant. Compared to the control group, Group K indicated more stable hemodynamics. Among postoperative complications, the incidence of dreaming was higher in Group K, with no significant differences in other complications. For postoperative pain, Group K had lower Numerical Rating Scale (NRS) scores at PACU discharge and on postoperative day 1 to day 3. The PACU stay was shorter in Group K.
CONCLUSION: Intraoperative low-dose esketamine effectively reduced hs-cTnT concentrations within 2 days postoperatively in elderly patients undergoing Ivor Lewis esophagectomy, demonstrating a potential beneficial effect in preventing myocardial injury and cardiovascular adverse events.
PMID:41913734 | PMC:PMC13033296 | DOI:10.2147/DDDT.S588535
