Eur J Med Res. 2025 Oct 27;30(1):1023. doi: 10.1186/s40001-025-03249-0.
ABSTRACT
AIM: This randomized controlled trial aimed to assess the efficacy of a combined Nd:YAG laser and bioactive glass (BAG) for dentin hypersensitivity following scaling and root planning (SRP). The study compared various desensitization protocols and evaluated the time-dependent effects of immediate desensitization therapy post-SRP.
METHODS: 80 patients with chronic periodontitis (200 sensitive teeth) were randomly assigned to five groups: group A (BAG), group B (Nd:YAG laser), group C (Nd:YAG laser + BAG), group D (BAG + Nd:YAG laser), and group E (control). Hypersensitivity was assessed via air-blast stimulation and measured on a Visual Analogue Scale (VAS) at baseline (T0), immediately after intervention (T1), and at 1-, 4-, and 8-week (T2-T4) post-treatment. Between-group comparisons of baseline characteristics and post-treatment measurements were analyzed with one-way ANOVA. Longitudinal comparisons across timepoints were evaluated using repeated-measures ANOVA. Categorical variables were compared by chi-square test.
RESULTS: No significant differences in demographic characteristics or baseline VAS scores were observed across the groups before treatment (P > 0.05). All interventional groups (A-D) showed significant and sustained reductions in VAS scores relative to both baseline and control (all P < 0.001), with group D achieving the greatest improvement at T4 (2.00 ± 0.68, P < 0.05 vs. group C). Effectiveness rates were also significantly higher in groups A-D than in group E (all P < 0.001). Combination therapies (C and D) proved superior to monotherapies (A and B), with group D maintaining the highest effectiveness rate through T4 (92.5%). A gradual decline in effectiveness was observed over time, being least pronounced in group D.
CONCLUSIONS: The combined application of BAG and Nd:YAG laser therapy demonstrated a significant reduction in dentin hypersensitivity post-SRP, exhibiting superior and sustained efficacy compared to monotherapies. Furthermore, the sequential treatment involving BAG applied prior to Nd:YAG laser irradiation showed the most pronounced therapeutic effect in symptom alleviation.
PMID:41146330 | DOI:10.1186/s40001-025-03249-0
