Sci Rep. 2025 Oct 22;15(1):36881. doi: 10.1038/s41598-025-20838-5.
ABSTRACT
Epidemiological evidence support the idea that CST I, L. crispatus-dominated vaginal microbiota, could protect women form cervical HPV infection also favoring the HPV clearance. Our prospective, multi-center, randomized, placebo-controlled trial on 62 women newly diagnosed of HPV infection without visible cervical lesions at colposcopy, was mainly aimed at evaluating the role exerted by the oral treatment (daily, 4 months) with the strain L. crispatus M247 in prompting the HR-HPV clearance and CST shift. The results of our study demonstrated that the probiotic treatment significantly increased versus control: (i) the HPV clearance (60% versus 31.8%), and (ii) the number of negative PAP tests (83.3% versus 71.4%), favoring also the vaginal microbiota eubiosis. Particularly, the vaginal microbiota analysis demonstrated a significant relationship between the observed HPV clearance and: (i) a reduced richness; (ii) an increased relative presence of L. crispatus; and (iii) an increased number of women with a CST I microbiota. While a larger study would further strengthen these findings, the current evidence provides encouraging insights into the potential efficacy of the oral treatment with the strain L. crispatus M247.
PMID:41125728 | DOI:10.1038/s41598-025-20838-5
