J Tradit Chin Med. 2025 Jun;45(3):633-638. doi: 10.19852/j.cnki.jtcm.2025.03.016.
ABSTRACT
OBJECTIVE: To evaluate the therapeutic effect of a self-formulated Traditional Chinese Medicine (TCM), Shugan Jieyu San, on improvement of liver function and depression alleviation in the patients with triple negative breast cancer (TNBC).
METHODS: A total of 60 patients diagnosed with TNBC and depression were enrolled and randomly assigned to either the control group (receiving routine tumor treatment and duloxetine) or the treatment group (receiving the TCM in addition to routine treatment).
RESULTS: Both treatment and control groups showed a reduction in depressive symptoms and improved daily living abilities after treatment. However, the treatment group demonstrated significantly better outcomes compared to the control group. Furthermore, the levels of dopamine and serotonin in the serum increased in both groups after 8 weeks of treatment, while the treatment group exhibited superior results.
CONCLUSIONS: This TCM showed promising results in reducing depressive symptoms and improving daily abilities in patients with TNBC and comorbid depression, which was verified by the increase in serum levels of dopamine and serotonin, suggesting the potential involvement of these neurotransmitters in the therapeutic effects of this TCM.
PMID:40524302 | DOI:10.19852/j.cnki.jtcm.2025.03.016
